| Date | Location | Result | |
| 11-19-10 | Rock Hill, SC | High Point 3, Charleston Southern 1 (23-25,26-24,25-18,25-22) | Box score |
| 11-18-10 | Rock Hill, SC | Charleston Southern 3, UNC Asheville 0 (25-19,25-11,25-18) | Box score |
| Nov 13, 2010 | Charleston, S.C. | Presbyterian College 3, Charleston Southern 1 (25-22,24-26,25-20,25-23) | Box score |
| Nov 12, 2010 | Charleston, S.C. | Charleston Southern 3, Gardner-Webb 1 (25-18,25-11,26-28,25-17) | Box score |
| Nov 06, 2010 | Asheville, N.C. | UNC Asheville 3, Charleston Southern 1 (23-25,27-25,25-16,25-20) | Box score |
| Nov 02, 2010 | Charleston, S.C. | Charleston Southern 3, Coastal Carolina 0 (25-22,25-17,25-11) | Box score |
| Oct 29, 2010 | Charleston, S.C. | Liberty 3, Charleston Southern 2 (23-25,25-11,20-25,25-17,15-11) | Box score |
| Oct 26, 2010 | Charleston, S.C. | Coll. of Charleston 3, Charleston Southern 0 (25-18,25-14,25-19) | Box score |
| 10/23/10 | Radford, Va. | Charleston Southern 3, Radford 0 (25-18,28-26,25-14) | Box score |
| 10-22-10 | High Point, NC | High Point 3, Charleston Southern 0 (25-13,25-21,25-19) | Box score |
| Oct 19, 2010 | Rock Hill, SC | Winthrop 3, Charleston Southern 0 (25-15,25-16,25-19) | Box score |
| Oct 16, 2010 | Boiling Springs, NC | Charleston Southern 3, Gardner-Webb 0 (29-27,25-16,25-19) | Box score |
| Oct 15, 2010 | Clinton, S.C. | Charleston Southern 3, Presbyterian College 1 (25-23,25-17,17-25,25-22) | Box score |
| Oct 12, 2010 | Charleston, S.C. | Charleston Southern 3, Savannah State 0 (25-9,25-13,25-22) | Box score |
| Oct 08, 2010 | Charleston, S.C. | UNC Asheville 3, Charleston Southern 2 (24-26,25-23,22-25,27-25,15-12) | Box score |
| 10-02-10 | Lynchburg, Va. | Liberty 3, Charleston Southern 0 (25-20,25-14,25-13) | Box score |
| Sep 28, 2010 | Charleston, S.C. | Winthrop 3, Charleston Southern 0 (25-19,27-25,25-23) | Box score |
| Sep 25, 2010 | Charleston, S.C. | High Point 3, Charleston Southern 1 (25-17,22-25,25-19,25-14) | Box score |
| Sep 24, 2010 | Charleston, S.C. | Charleston Southern 3, Radford 0 (25-16,25-18,25-21) | Box score |
| Sep 21, 2010 | Conway, S.C. | Coastal Carolina 3, Charleston Southern 0 (25-16,25-20,25-23) | Box score |
| Sep 18, 2010 | Statesboro, Ga. | Georgia Southern 3, Charleston Southern 0 (25-15,25-12,25-17) | Box score |
| Sep 18, 2010 | Statesboro, Ga. | Charleston Southern 3, South Alabama 2 (21-25,25-12,19-25,25-21,15-11) | Box score |
| Sep 17, 2010 | Statesboro, Ga. | East Tennessee State 3, Charleston Southern 0 (26-24,25-21,25-16) | Box score |
| Sep 11, 2010 | Jacksonville, Fla. | Charleston Southern 3, Chattanooga 2 (25-20,25-21,21-25,25-27,15-13) | Box score |
| Sep 11, 2010 | Jacksonville, Fla. | Charleston Southern 3, North Florida 1 (25-20,19-25,25-23,25-20) | Box score |
| Sep 10, 2010 | Jacksonville, Fla. | Troy 3, Charleston Southern 0 (25-22,28-26,25-17) | Box score |
| Sep 10, 2010 | Jacksonville, Fla. | Illinois Chicago 3, Charleston Southern 1 (25-20,21-25,25-19,25-19) | Box score |
| Sep 07, 2010 | Charleston, S.C. | UNCW 3, Charleston Southern 2 (18-25,26-24,14-25,27-25,15-11) | Box score |
| Aug 31, 2010 | Charleston, SC | Charleston Southern 3, The Citadel 2 (25-20,25-23,19-25,19-25,15-9) | Box score |
| Aug 28, 2010 | Durham, NC | UTEP 3, Charleston Southern 0 (25-13,27-25,25-23) | Box score |
| Aug 28, 2010 | Durham, NC | Delaware State 3, Charleston Southern 1 (18-25,27-25,26-24,25-20) | Box score |
| Aug 27, 2010 | Durham, N.C. | Charleston Southern 3, N.C. Central 0 (25-17,25-21,25-17) | Box score |
| Aug 27, 2010 | Durham, NC | Elon 3, Charleston Southern 1 (27-29,25-18,25-18,25-12) | Box score |